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ما هو الالتهام الذاتي؟

25 فبراير 2017

الالتهام الذاتي (Autophagy) (من الكلمة اليونانية auto-:"ذاتي" و phagein "يلتهم") هي آلية تدمير طبيعية تُفكّك، بصورة منظّمة، المكوّنات الخلوية غير...

الالتهام الذاتي (Autophagy) (من الكلمة اليونانية auto-:"ذاتي" و phagein "يلتهم") هي آلية تدمير طبيعية تُفكّك، بصورة منظّمة، المكوّنات الخلوية غير الضرورية أو المعطوبة.

تسمح عملية الالتهام الذاتي بالتقويض المُنظّم وإعادة التدوير للمكونات الخلوية.

وخلال هذه العملية، يتم عزل المكونات الحشوية المستهدفة عن بقية الخلية داخل حويصلة غشائية مزدوجة تعرف باسم جسيم الالتهام الذاتي. يندمج بعدئذ هذا الجسيم مع جسيم حال، ثم تتحلل المكونات ويُعاد تشكيلها. هناك ثلاث أشكال مختلفة للالتهام الذاتي: الالتهام الذاتي الكبير ( macroautophagy) والالتهام الذاتي الصغير (microautophagy) والالتهام الذاتي المتوسط الموجّه ( chaperone-mediated autophagy). وفي سياق التشخيص المرضي، تعتبر عملية الالتهام الذاتي استجابة تكيُفيّة للضغوط، مما يعزز فرص البقاء على قيد الحياة، بينما في حالات أخرى تكون سببًا لموت الخلايا والمرض. في حالة الجوع الشديد، يعمل انهيار المكونات الخلوية على تعزيز بقاء الخلايا من خلال الحفاظ على مستويات الطاقة الخلوية.

وقد صيغ مصطلح «الالتهام الذاتي» على يد عالم الكيمياء الحيوية البلجيكي كريستيان دو دوف سنة 1963 م.

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